5-Hydroxymethylcytosine Loss in Conjunctival Melanoma
نویسندگان
چکیده
منابع مشابه
Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma
DNA methylation at the 5 position of cytosine (5-mC) is a key epigenetic mark that is critical for various biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the ten-eleven translocation (TET) family of DNA hydroxylases. Here, we report that "loss of 5-hmC" is an epigenetic hallmark of melanoma, with diagnostic and prognostic implications. Genome-...
متن کاملReplication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos.
Although global erasure of DNA methylation has been observed in zygotes and primordial germ cells, the responsible enzyme(s) have been elusive. The demonstration that members of the Tet (ten eleven translocation) family of proteins are capable of catalyzing conversion of 5-methylcytosine (5mC) of DNA to 5-hydroxymethylcytosine (5hmC) raises the possibility that Tet proteins may participate in t...
متن کاملConjunctival melanoma.
and similar software but a long sequence of consecutive tests is required.12 It might therefore be more effective if a less sensitive test was used in the first place. With the appearance of FASTPAC and other simple test programs it seems that computerised field analysis is approaching the performance of machines such as the venerable Friedmann visual field analyser. Is the emperor's new suit b...
متن کاملConjunctival melanoma.
and similar software but a long sequence of consecutive tests is required.12 It might therefore be more effective if a less sensitive test was used in the first place. With the appearance of FASTPAC and other simple test programs it seems that computerised field analysis is approaching the performance of machines such as the venerable Friedmann visual field analyser. Is the emperor's new suit b...
متن کاملLoss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma
Melanomas in the vertical growth phase (VGP) not infrequently demonstrate cellular heterogeneity. One commonly encountered subpopulation displays small cell/nevoid morphology. Although its significance remains unknown, such subpopulations may pose diagnostic issues when faced with differentiating such changes from associated nevus or mistaking such regions for nevic maturation (pseudomaturation...
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ژورنال
عنوان ژورنال: Dermatopathology
سال: 2021
ISSN: 2296-3529
DOI: 10.3390/dermatopathology8020023